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Mod GRF 1-29 dosage and protocol
Last reviewed Oct 7, 2026. Editorial policy
Modified GRF (also known as CJC-1295 without DAC). Pulsatile GH release with shorter half-life for anti-aging and fat loss support.
- Vial size: 2 mg
- Reconstitution: 2 mL bacteriostatic water
- Concentration: 1mg/mL
- Administration: subcutaneous
Research areas
- Growth Hormone
- Anti-Aging
- Fat Loss Support
- Recovery
- Muscle Preservation
Quick start
- Reconstitute: Add 2 mL bacteriostatic water to the 2 mg vial for 1 mg/mL
- Typical dose: 100-200 mcg subcutaneous 1-2x daily, or 100 mcg before bed
- Easy measuring: At 1 mg/mL, 1 unit = 10 mcg on a U-100 syringe; 100 mcg = 10 units, 200 mcg = 20 units
- Storage: Refrigerate after mixing; use within 4-6 weeks
Dosing protocol
| Phase | Dose | Frequency | Volume |
|---|---|---|---|
| Standard | 100-200mcg | 1-2x daily, often stacked with Ipamorelin | 0.1-0.2 |
| Evening Protocol | 100mcg | before bed | 0.1 |
How it works
MOD-GRF 1-29, also called CJC-1295 without DAC or modified GRF (1-29), is a synthetic version of the first 29 amino acids of growth hormone-releasing hormone (GHRH), the active fragment of the natural hormone. Four amino acid substitutions protect it from rapid breakdown by DPP-4 and other enzymes, extending its half-life from a few minutes to roughly 30 minutes. It binds the GHRH receptor on pituitary somatotroph cells, raising cAMP and triggering a pulse of growth hormone (GH) release, which in turn increases IGF-1 production in the liver. Because it lacks the drug affinity complex (DAC) that makes CJC-1295 last for days, it produces short, physiological GH pulses rather than a continuous elevation. It is often paired with a ghrelin-mimetic such as ipamorelin, since GHRH analogs and GH secretagogues act on different receptors and produce a larger combined GH pulse in physiological studies. The broader GHRH-analog class has human data: tesamorelin, a related analog, is FDA-approved to reduce excess abdominal fat in people with HIV-associated lipodystrophy, and sermorelin was previously approved for pediatric GH deficiency. MOD-GRF 1-29 itself, however, has not completed formal clinical trials, so its specific dosing and long-term safety are based on extrapolation rather than controlled evidence.
Units chart for a 2 mg vial
| Water added | Strength | 1 unit = | 100 mcg |
|---|---|---|---|
| 1 mL | 2 mg/mL | 20 mcg | 5 units |
| 2 mL | 1 mg/mL | 10 mcg | 10 units |
| 3 mL | 0.67 mg/mL | 6.7 mcg | 15 units |
Units on a U-100 insulin syringe (100 units = 1 mL).
Pages for each vial size and water volume
Reconstitution steps
- Draw 2.0 mL bacteriostatic water with a sterile syringe
- Inject slowly down the vial wall; avoid foaming
- Gently swirl/roll until dissolved (do not shake)
- Label with reconstitution date and refrigerate at 2–8°C, protected from light; use within 30 days
Storage
Evidence: Common practice. What vendors and users usually do. No published stability testing supports a specific number.
- Powder or unopened: Sealed powder: freezer (about −20 °C) for long-term storage, refrigerator for weeks. Let the vial reach room temperature before opening.
- Mixed or in use: Refrigerator, 2–8 °C. Do not freeze and thaw repeatedly.
- Use within: no tested number
- Light: Keep it in the box or another dark container.
Most reconstituted peptides are kept in the refrigerator (2–8 °C) and used within about 28 days. That is a convention, not tested data: the 28 days comes from the USP <797> limit for opened multiple-dose containers, which is about sterility, not about whether the peptide stays intact.
Sources: Crestigen: Peptide storage and handling guide; USP General Chapter <797> Pharmaceutical Compounding: Sterile Preparations
Store reconstituted peptide refrigerated. Use within 4-6 weeks when refrigerated.
Important notes
- Same as CJC-1295 without DAC - short-term GH release
- Mimics natural GH axis - requires frequent dosing
- Mild flushing or tingling may occur
- Supports natural GH axis without prolonged elevation
- Often combined with GHRP-2, GHRP-6, or Ipamorelin for synergy
- Short half-life requires frequent dosing for optimal results
Supplies
- Bacteriostatic water
- Insulin syringes
- Alcohol swabs